期刊
BIOMATERIALS
卷 238, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2020.119847
关键词
Mesoporous polydopamine; Photothermal-responsive; Plasmonic nanostructures; Traceable protein delivery; Cancer therapy
资金
- National Natural Science Foundation of China [21473157, 81872807]
- Fundamental Research Funds for the Central Universities [2018XZZX001-14]
- Ministry of Education-Singapore [M0E2015-T2-1-112, MOE2013-T3-1-002]
- China Scholarship Council [201706320290]
Functional proteins are essential for the regulation of cellular behaviors and have found growing therapeutic uses. However, low bioavailability of active proteins to their intracellular targets has been a long-standing challenge to achieve their full potential for cell reprogramming and disease treatment. Here we report mesoporous polydopamine (mPDA) with a built-in plasmonic nanoparticle core as a multifunctional protein delivery system. The mPDA with a unique combination of large surface area, metal-chelating property, and broad-spectrum photothermal transduction allows efficient loading and near-infrared light-triggered release of functional proteins, while the plasmonic core serves as a photostable tracer and fluorescence quencher, collectively leading to real-time monitoring and active cytosolic release of model proteins. In particular, controlled delivery of cytotoxic ribonuclease A has shown excellent performance in in vivo cancer therapy. The possibility of coating mPDA on a broad range of functional cores, thanks to its universal adhesion, provides opportunities for developing tailored delivery carriers of biologics to overcome intrinsic biological barriers.
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