期刊
BIOLOGY OF THE CELL
卷 112, 期 6, 页码 153-172出版社
WILEY
DOI: 10.1111/boc.201900090
关键词
brain development and brain growth disorders; centrosomes; mitotic spindle assembly and disorganisation; mitotic errors; neural stem cell division and fitness
类别
资金
- CNRS
- Institut Curie
- WorldWide Cancer [13-0170]
- ANR (ANR-DIVACEN) [14-CE11]
- ERC consolidator grant Chromo [725907]
- Labex CelTisPhyBio [ANR-11-LABX-0038, ANR-10-IDEX-0001-02]
- European Research Council (ERC) [725907] Funding Source: European Research Council (ERC)
Centrosomes nucleate and organise the microtubule cytoskeleton in animal cells. These membraneless organelles are key structures for tissue organisation, polarity and growth. Centrosome dysfunction, defined as deviation in centrosome numbers and/or structural integrity, has major impact on brain size and functionality, as compared with other tissues of the organism. In this review, we discuss the contribution of centrosomes to brain growth during development. We discuss in particular the impact of centrosome dysfunction in Drosophila and mammalian neural stem cell division and fitness, which ultimately underlie brain growth defects.
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