期刊
BIOLOGICAL TRACE ELEMENT RESEARCH
卷 199, 期 1, 页码 113-119出版社
SPRINGERNATURE
DOI: 10.1007/s12011-020-02139-2
关键词
Milk; Nano-Se; Glutathione peroxidase; Selenoprotein; Dairy cow
资金
- China Agriculture Research System [CARS-36]
- National Natural Science Foundation of China [U1904116]
- Foundation of Bosar Biotechnology Research Company
The study showed that supplementation with Nano-Se resulted in higher milk Se levels and GSH-Px activities in dairy cows compared to sodium selenite. Nano-Se also increased plasma Se levels and GSH-Px activity, as well as upregulated the expression of antioxidant related genes in mammary glands.
Supplementation with selenium is common for dairy cows, but the importance of selenium source is not clear. This study aimed to compare nano-selenium (Nano-Se) and sodium selenite supplements for dairy cows on lactation performance, milk Se levels and selenoprotein (Sel) gene expression. Twelve multiparous Holstein cows were randomly divided into two groups: a control group fed a basal diet plus 0.30 mg Se/kg of DM as sodium selenite or Nano-Se for 30 days. Dry matter intake, milk yield and composition were not affected by dietary Se source (P > 0.05); however, the milk total Se levels and milk glutathione peroxidase (GSH-Px) activities were higher with Nano-Se supplementation than sodium selenite (P < 0.05). At the end of the experiment, Nano-Se supplementation significantly increased plasma Se levels and GSH-Px activity, compared with the sodium selenite supplement. The mRNA expression levels of glutathione peroxidase 1, 2 and 4; thioredoxin reductase 2 and 3; and selenoproteins W, T, K and F were markedly upregulated (P < 0.05) in the mammary gland of the Nano-Se group. Thus, the source of selenium plays an important role in the antioxidant status and in particular the Sel gene expression in the mammary glands of dairy cows, both being stimulated by nano sources.
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