期刊
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
卷 1873, 期 2, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbcan.2020.188361
关键词
Ovarian cancer; Tumor microenvironment; Growth; Metastasis; Stromal cells; Immune cells
资金
- National Natural Science Foundation of China [81822034, 81773119, 81821002]
- National Key Research and Development Program of China [2018YFA0109200, 2017YFA0106800]
- Sichuan Science-Technology International Cooperation Project [2019YFH0144]
- West China Second Hospital, Sichuan University [KS021, K1907]
Ovarian cancer is the leading cause of gynecological cancer-related mortality globally. The majority of ovarian cancer patients suffer from relapse after standard of care therapies and the clinical benefits from cancer therapies are not satisfactory owing to drug resistance. Certain novel drugs targeting the components of tumor micro-environment (TME) have been approved by US Food and Drug Administration in solid cancers. As such, the passion is rekindled to exploit the role of TME in ovarian cancer progression and metastasis for discovery of novel therapeutics for this deadly disease. In the current review, we revisit the recent mechanistic insights into the contributions of TME to the development, progression, prognosis prediction and therapeutic efficacy of ovarian cancer via modulating cancer hallmarks. We also explored potentially promising predictive and prognostic biomarkers for ovarian cancer patients.
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