期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1866, 期 5, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2020.165706
关键词
Trypanosoma cruzi; Chagas' disease; Interleukin 17; TH17 cells; Protozoan infections
资金
- Agencia Nacional de Promocion Cientifica y Tecnologica [PICT 2015-0127, PICT 2015-0645]
- Consejo Nacional de Investigaciones Cientificas y Tecnicas, CONICET [PIP 112-20110100378]
- Secretaria de Ciencia y Tecnica-Universidad Nacional de Cordoba
- National Institute of Allergy and Infectious Diseases of the National Institutes of Health [R01AI110340, R01AI116432]
- CONICET
Host resistance during infection with Trypanosoma cruzi, and other protozoans, is dependent on a balanced immune response. Robust immunity against these pathogens requires of the concerted action of many innate and adaptive cell populations including macrophages, neutrophils, dendritic cells, CD4(+), and CD8(+) T cells and B cells among others. Indeed, during most protozoan infections only a balanced production of inflammatory (T(H)1) and anti-inflammatory (T(H)2/regulatory) cytokines will allow the control of parasite spreading without compromising host tissue integrity. The description of T(H)17 cells, a novel effector helper T cell lineage that produced IL-17 as signature cytokine, prompted the revision of our knowledge about the mechanisms that mediate protection and immunopathology during protozoan infections. In this manuscript we discuss the general features of IL-17 mediated immune responses as well as the cellular sources, effector mechanisms and overall role of IL-17 in the immune response to T. cruzi and other protozoan infections.
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