期刊
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
卷 1866, 期 10, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbadis.2020.165778
关键词
Exercise; Brain function; Neuroprotection; Alzheimer diseases; Parkinson's disease; Ischemia reperfusion; Redox homeostasis
资金
- OTKA [112810]
- National Excellence Program, at the University of Physical Education, Innovation and Technology Ministry, Hungary [126823]
- Scientific Excellence Program, at the University of Physical Education, Innovation and Technology Ministry, Hungary [TUDFO/51757/2019-ITM]
Regular exercise induces a wide range of redox system-associated molecular adaptive responses to the nervous system. The intermittent induction of reactive oxygen species (ROS) during acute exercise sessions and the related upregulation of antioxidant/repair and housekeeping systems are associated with improved physiological function. Exercise-induced proliferation and differentiation of neuronal stem cells are ROS dependent processes. The increased production of brain derived neurotrophic factor (BDNF) and the regulation by regular exercise are dependent upon redox sensitive pathways. ROS are causative and associative factors of neurodegenerative diseases and regular exercise provides significant neuroprotective effects against Alzheimer's disease, Parkinson's disease, and hypoxia/reperfusion related disorders. Regular exercise regulates redox homeostasis in the brain with complex multi-level molecular pathways.
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