期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 526, 期 1, 页码 165-169出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2020.03.047
关键词
SARS-CoV-2; Spike protein; ACE2; Structure; Host range
资金
- National Key Plan for Research and Development of China [2016YFD0500300]
- National Natural Science Foundation of China [81871663, 81672035]
- Shandong Academy of Medical Sciences Grant [2017-52]
- Academic promotion programme of Shandong First Medical University
- NIH [P41-GM103311]
SARS-CoV-2 causes the recent global COVID-19 public health emergency. ACE2 is the receptor for both SARS-CoV-2 and SARS-CoV. To predict the potential host range of SARS-CoV-2, we analyzed the key residues of ACE2 for recognizing S protein. We found that most of the selected mammals including pets (dog and cat), pangolin and Circetidae mammals remained the most of key residues for association with S protein from SARS-CoV and SARS-CoV-2. The interaction interface between cat/dog/pangolin/Chinese hamster ACE2 and SARS-CoV/SARS-CoV-2 S protein was simulated through homology modeling. We identified that N82 in ACE2 showed a closer contact with SARS-CoV-2 S protein than M82 in human ACE2. Our finding will provide important insights into the host range of SARS-CoV-2 and a new strategy to design an optimized ACE2 for SARS-CoV-2 infection. (C) 2020 Elsevier Inc. All rights reserved.
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