期刊
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
卷 685, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.abb.2020.108349
关键词
Breast cancer; FOXM1; YAP1; Cancer stemness
资金
- Beijing Natural Science Foundation [7192014]
- Open Project of Key Laboratory of Genomics and Precision Medicine, Chinese Academy of Sciences
- Importation and Development of High-Caliber Talents Project of Beijing Municipal Institutions [CIT TCD201304054]
- National Natural Science Foundation of China of China [30800580]
- National Laboratory of Biomacromolecules [2017kf02]
- practical training plan for the cross training of high level talents in Beijing Universities [2017271]
Breast cancer has the highest incidence and mortality in the female population. Forkhead box M1 (FOXM1) known as a transcription factor is upregulated and associated with poor prognosis in a variety of cancers. However, the molecular mechanisms of FOXM1 on breast cancer progression are poorly understood. In this study, we found that FOXM1 was up-regulated in breast cancer. FOXM1 promoted cell proliferation, clonal formation, and migration capacity in triple negative breast cancer by increasing transcriptional activity of YAP1. FOXM1 also maintained cell stemness via the Hippo pathway. The YAP1-TEAD binding inhibitor Verteporfin reduced the transcription level of OCT4 and NANOG but the Hippo pathway activator XMU-MP-1 could increase the transcription level of OCT4 and NANOG. In summary, our findings indicated that FOXM1 promoted breast cancer progression through the Hippo pathway, and it was suggested a new strategy to treat breast cancer.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据