期刊
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
卷 -, 期 -, 页码 -出版社
SPRINGER
DOI: 10.1007/s00253-020-10560-9
关键词
Alzheimer's disease; Microbial acetylcholinesterase inhibitors; Huperzine A; Irradiation; Nano-material-based drug delivery systems
资金
- Nuclear Research Center, Atomic Energy Authority, Egypt
- P.I. of Nanotechnology Research Unit
Neurodegenerative disorders especially Alzheimer's disease (AD) are significantly threatening the public health. Acetylcholinesterase (AChE) inhibitors are compounds of great interest which can be used as effective agents for the symptomatic treatment of AD. Although plants are considered the largest source for these types of inhibitors, the microbial production of AChE inhibitors represents an efficient, easily manipulated, eco-friendly, cost-effective, and alternative approach. This review highlights the recent advances on the microbial production of AChE inhibitors and summarizes all the previously reported successful studies on isolation, screening, extraction, and detecting methodologies of AChE inhibitors from the microbial fermentation, from the earliest trials to the most promising anti-AD drug, huperzine A (HupA). In addition, improvement strategies for maximizing the industrial production of AChE inhibitors by microbes will be discussed. Finally, the promising applications of nano-material-based drug delivery systems for natural AChE inhibitor (HupA) will also be summarized.
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