期刊
ANTIOXIDANTS & REDOX SIGNALING
卷 33, 期 4, 页码 247-262出版社
MARY ANN LIEBERT, INC
DOI: 10.1089/ars.2020.8093
关键词
hypoxic-ischemic encephalopathy; mitochondrial dysfunction; neonatal encephalopathy; perinatal asphyxia; free radicals
资金
- Universidad de la Republica (Centro de Investigaciones Biomedicas Espacio Interdisciplinario 2015), Universidad de la Republica, Uruguay
- Universidad de la Republica (CSIC_Grupos 2018), Universidad de la Republica, Uruguay
- Programa de Desarrollo de Ciencias Basicas (Uruguay)
Significance: Hypoxic-ischemic events due to intrapartum complications represent the second cause of neonatal mortality and initiate an acute brain disorder known as hypoxic-ischemic encephalopathy (HIE). In HIE, the brain undergoes primary and secondary energy failure phases separated by a latent phase in which partial neuronal recovery is observed. A hypoxic-ischemic event leads to oxygen restriction causing ATP depletion, neuronal oxidative stress, and cell death. Mitochondrial dysfunction and enhanced oxidant formation in brain cells are characteristic phenomena associated with energy failure. Recent Advances: Mitochondrial sources of oxidants in neurons include complex I of the mitochondrial respiratory chain, as a key contributor to O-2(center dot-) production via succinate by a reverse electron transport mechanism. The reaction of O-2(center dot-) with nitric oxide ((NO)-N-center dot) yields peroxynitrite, a mitochondrial and cellular toxin. Quantitation of the redox state of cytochrome c oxidase, through broadband near-infrared spectroscopy, represents a promising monitoring approach to evaluate mitochondrial dysfunction in vivo in humans, in conjunction with the determination of cerebral oxygenation and their correlation with the severity of brain injury. Critical Issues: The energetic failure being a key phenomenon in HIE connected with the severity of the encephalopathy, measurement of mitochondrial dysfunction in vivo provides an approach to assess evolution, prognosis, and adequate therapies. Restoration of mitochondrial redox homeostasis constitutes a key therapeutic goal. Future Directions: While hypothermia is the only currently accepted therapy in clinical management to preserve mitochondrial function, other mitochondria-targeted and/or redox-based treatments are likely to synergize to ensure further efficacy.
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