期刊
ANTICANCER RESEARCH
卷 40, 期 5, 页码 2871-2880出版社
INT INST ANTICANCER RESEARCH
DOI: 10.21873/anticanres.14263
关键词
Breast cancer; neutrophil-to-lymphocyte ratio; tumour-infiltrating lymphocytes; prognosis
类别
Background/Aim: This study aimed to improve the prognostic significance of neutrophil-to-lymphocyte ratio (NLR) and tumour-infiltrating lymphocytes (TILs). Patients and Methods: In this retrospective study, NLR and TIL data from 677 operated breast cancer patients were analysed. The cut-off value of NLR was set at 2.72, and TIL levels were classified as low (<10%), intermediate (>= 10 to <50%), and high (>= 50%). Results: Recurrence free survival (RFS) was significantly longer in patients with low NLR (n=459) than in those with high NLR (n=218) (p=0.0383). In ER-positive/HER2-negative and TIL-low breast cancers, there were significant associations between NLR levels and RFS (p=0.0129) or overall survival (OS) (p=0.0046). On multivariate analysis, NLR was a significant and independent factor for OS (hazard ratio=3 .78; 95% confidence interval=1.21-14.17; p=0.022). Conclusion: These data may be useful for predicting patient prognosis and understanding the clinical significance of immune status in breast cancers.
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