期刊
ANTI-CANCER AGENTS IN MEDICINAL CHEMISTRY
卷 21, 期 7, 页码 825-838出版社
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1871520620666200516150345
关键词
Anti-cancer agents; quinoline derivatives; marketed drugs; clinical trials; molecular targets; major mechanisms
资金
- Guangxi University for Nationalities Research Funded Project, China [2018KJQD13]
- Guangxi Minority Preparatory Education Base Research Project, China [2017B002]
- Guangxi Biological Polysaccharide Separation, Purification and Modification Research Platform, China [GKZY18076005]
This review focuses on the utilization of quinoline derivatives in medicinal chemistry for developing anti-cancer drugs, discussing representative drugs or candidates and their main mechanisms. It provides a comprehensive overview of the relationship between drugs within the same mechanism, with insights into future prospects. The review aims to assist researchers interested in discovering quinoline derivative anti-cancer agents by summarizing, discussing, and highlighting potential challenges in the field.
Background: Along with the progress in medicine and therapies, the exploitation of anti-cancer agents focused more on the vital signaling pathways and key biological macromolecules. With rational design and advanced synthesis, quinoline derivatives have been utilized frequently in medicinal chemistry, especially in developing anti-cancer drugs or candidates. Methods: Using DOI searching, articles published before 2020 all over the world have been reviewed as comprehensively as possible. Results: In this review, we selected the representative quinoline derivate drugs in market or clinical trials, classified them into five major categories with detailed targets according to their main mechanisms, discussed the relationship within the same mechanism, and generated a summative discussion with prospective expectations. For each mechanism, the introduction of the target was presented, with the typical examples of quinoline derivate drugs. Conclusion: This review has highlighted the quinoline drugs or candidates, suited them into corresponding targets in their pathways, summarized and discussed. We hope that this review may help the researchers who are interested in discovering quinoline derivate anti-cancer agents obtain considerable understanding of this specific topic. Through the flourishing period and the vigorous strategies in clinical trials, quinoline drugs would be potential but facing new challenges in the future.
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