期刊
ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 58
卷 58, 期 -, 页码 139-160出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-phyto-010820-012733
关键词
RPS5; PBS1; decoy engineering; Arabidopsis; soybean; NLR
资金
- National Institute of General Medical Sciences of the US National Institutes of Health [R01 GM046451]
- US National Science Foundation Plant Biotic Interactions program [IOS-1551452]
Focusing on the discovery and characterization of the Arabidopsis disease resistance protein RPS5 and its guardee PBS1, this review discusses work done in the Innes laboratory from the initial identification of the RPS5 gene in 1995 to the recent deployment of the PBS1 decoy system in crops. This is done through discussion of the structure, function, and signaling environment of RPS5 and PBS1, highlighting collaborations and influential ideas along the way. RPS5, a nucleotide-binding leucine-rich repeat (NLR) protein, is activated by the proteolytic cleavage of PBS1. We have shown that the cleavage site within PBS1 can be altered to contain cleavage sites for other proteases, enabling RPS5 activation by these proteases, thereby conferring resistance to different pathogens. This decoy approach has since been translated into crop species using endogenous PBS1 orthologs and holds strong potential for GMO-free development of new genetic resistance against important crop pathogens.
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