期刊
ANNUAL REVIEW OF IMMUNOLOGY, VOL 38
卷 38, 期 -, 页码 511-539出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-immunol-082619-124440
关键词
host-pathogen interactions; natural killer cells; viral immunoevasion; natural killer cell receptors; NKG2D ligands; pathogenic viruses
类别
资金
- Fonds de recherche Quebec-sante (FRQS)
- Canada Research Chairs Program
- Canadian Institutes of Health Research (CIHR)
The continuous interactions between host and pathogens during their co-evolution have shaped both the immune system and the countermeasures used by pathogens. Natural killer (NK) cells are innate lymphocytes that are considered central players in the antiviral response. Not only do they express a variety of inhibitory and activating receptors to discriminate and eliminate target cells but they can also produce immunoregulatory cytokines to alert the immune system. Reciprocally, several unrelated viruses including cytomegalovirus, human immunodeficiency virus, influenza virus, and dengue virus have evolved a multitude of mechanisms to evade NK cell function, such as the targeting of pathways for NK cell receptors and their ligands, apoptosis, and cytokine-mediated signaling. The studies discussed in this article provide further insights into the antiviral function of NK cells and the pathways involved, their constituent proteins, and ways in which they could be manipulated for host benefit.
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