期刊
ANNUAL REVIEW OF BIOCHEMISTRY, VOL 89
卷 89, 期 -, 页码 103-133出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-biochem-011520-104722
关键词
checkpoint; DNA double-strand break; DNA repair; kinases; cell cycle
资金
- National Institutes of Health (NIH) [R01GM61766, R35GM127029, R01GM097272, R01HD095296]
- NIH Genetics Training Grant [TM32 GM007122]
Cells confront DNA damage in every cell cycle. Among the most deleterious types of DNA damage are DNA double-strand breaks (DSBs), which can cause cell lethality if unrepaired or cancers if improperly repaired. In response to DNA DSBs, cells activate a complex DNA damage checkpoint (DDC) response that arrests the cell cycle, reprograms gene expression, and mobilizes DNA repair factors to prevent the inheritance of unrepaired and broken chromosomes. Here we examine the DDC, induced by DNA DSBs, in the budding yeast model system and in mammals.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据