期刊
CARDIOVASCULAR RESEARCH
卷 109, 期 4, 页码 502-509出版社
OXFORD UNIV PRESS
DOI: 10.1093/cvr/cvw001
关键词
Atrial fibrillation; Adipose tissue; Atrial fibrosis; Adipokines
资金
- Fondation Leducq 'Structural alterations in the myocardium and the substrate for cardiac fibrillation'
- European Union [EUTRAF - 261057]
- French National Agency through the National program 'Investissements d'avenir' [ANR-10-IAHU-05]
The amount of adipose tissue that accumulates around the atria is associated with the risk, persistence, and severity of atrial fibrillation (AF). A strong body of clinical and experimental evidence indicates that this relationship is not an epiphenomenon but is the result of complex crosstalk between the adipose tissue and the neighbouring atrial myocardium. For instance, epicardial adipose tissue is a major source of adipokines, inflammatory cytokines, or reactive oxidative species, which can contribute to the fibrotic remodelling of the atrial myocardium. Fibro-fatty infiltrations of the subepicardium could also contribute to the functional disorganization of the atrial myocardium. The observation that obesity is associated with distinct structural and functional remodelling of the atria has opened new perspectives of treating AF substrate with aggressive risk factor management. Advances in cardiac imaging should lead to an improved ability to visualize myocardial fat depositions and to localize AF substrates.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据