Vena capitis prima and the cavernous sinus in human embryos and fetuses

After the intracranial venous-drainage route is switched from the vena capitis prima (VCP) to the transverse sinus, the cavernous sinus is considered to develop from a connecting part of the VCP with the ophthalmic vein (OPV). Observations of histological sections from 12 embryos and 47 fetuses (6-35 weeks) demonstrated that (1) at six weeks, a major tributary of the VCP ran inferiorly in the plica ventralis at the mesencephalic flexure (future tentrium cerebelli) and merged with the OPV in the medial side of the trigeminal ganglion; (2) at seven weeks, being independent of the laterally located primary veins, the superior petrosal sinus (SPS) developed medially in the plica, ran superiorly, and appeared to make an initial confluence with the transverse sinus; (3) until 15-16 weeks, parasellar veins were limited to a few branches of the OPV without communication with the SPS on the lateral surface of the trigeminal ganglion; (4) after 15-16 weeks, parasellar veins increased in number and volume but did not yet drain into the SPS but rather into the newly built inferior petrosal sinus; and (5) near term, parasellar veins started venous drainage to the SPS, whereas few veins were evident around the intracavernous abducens nerve. Consequently, the inferior petrosal sinus might originate from a remnant of the VCP (the so-called pro-otic sinus), but after midterm, most parasellar veins appeared to develop from the OPV without any contribution of the SPS. These findings suggest that parasellar sinus-network might be established after birth. (C) 2020 Elsevier GmbH. All rights reserved.