期刊
ANIMAL BIOTECHNOLOGY
卷 32, 期 6, 页码 792-797出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10495398.2020.1753756
关键词
Litter size; CNV; goat; genome-wide sequence
资金
- Fundamental Research Funds for the Central Universities [XDJK2018B014]
- Open Project Program of State Key Laboratory of Barley and Yak Germplasm Resources and Genetic Improvement (Tibet Academy of Agricultural and Animal Husbandry Science (TAAAS), Lhasa, China)
- National Natural Science Foundation of China [31172195, 31301944]
- Chongqing Research Program of Basic Research and Frontier Technology [cstc2018jcyjAX0153, cstc2017shms-zdyfX0059, cstc2019jscx-gksbX0135]
This study aimed to identify the CNV associated with litter size in Dazu black goats based on unpublished sequencing data. CBLB gene was found to potentially affect litter size, with Chr1_50215501 identified as an effective genetic marker for marker-assisted selection breeding. The study helps understand the molecular mechanisms related to goat litter size.
This study aims to identify the relative Copy number variation (CNV) associated with the litter size of Dazu black goats based on the unpublished CNV analytical results of our previously published sequencing data, in which the litter-size groups were classified into extreme low- and high-yield groups. Firstly, to compare the existence of valuable CNV in Dazu black goats with different fertility levels with mixed pools. We obtained 4992 and 4888 CNVs from the HY and LY, which overlapping 1461 genes, and classified on the original CNV type. Three genes [LOC108633278,PPP1R12A, andYIPF4] were observed in the intersection between the HY deletion and the LY duplication groups. Secondly, on individuals level, we identified a novel candidate CNV (Chr1_50215501,F-ST= 0.148,V-ST= 0.347) from 214 autosomal credible CNVs to be significant with litter size in the Dazu black goat, which located in theCBLBgene. This finding indicates theCBLBgene may affect the litter size of the Dazu black goats through structural variations, and Chr1_50215501 can be an effective genetic marker for marker-assisted selection breeding, and this study was also helps understand the molecular mechanism related to the goat litter size.
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