期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 32, 页码 13288-13294出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202002208
关键词
alkynes; amides; C-H activation; axial chirality; rhodium
资金
- NSFC [21525208]
Reported herein is the atroposelective synthesis of biaryl NH isoquinolones by Rh-III-catalyzed C-H activation of benzamides and intermolecular [4+2] annulation for a broad scope of 2-substituted 1-alkynylnaphthalenes, as well as sterically hindered, symmetric diarylacetylenes. The axial chirality is constructed based on dynamic kinetic transformation of the alkyne in redox-neutral annulation with benzamides, with alkyne insertion being stereodetermining. The reaction accommodates both benzamides and heteroaryl carboxamides and proceeds in excellent regioselectivity (if applicable) and enantioselectivities (average 91.8 % ee). An enantiomerically and diastereomerically pure rhodacyclic complex was prepared and offers insight into enantiomeric control of the coupling system, wherein the steric interactions between the amide directing group and the alkyne substrate dictate both the regio- and enantioselectivity.
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