期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 34, 页码 14458-14465出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202002452
关键词
chemo; photothermal therapy; drug release; nanomotors; tumor permeability
资金
- Social development project of Jiangsu Natural Science Foundation [BE2019744]
- Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, National Natural Science Foundation of China [51641104, 21603105]
- Natural Science Foundation of Jiangsu Province [BK20171115]
- Priority Academic Program Development of Jiangsu Higher Education Institution
Limited tumor permeability of therapeutic agents is a great challenge faced by current cancer therapy methods. Herein, a kind of near infrared light (NIR)-driven nanomotor with autonomous movement, targeted ability, hierarchical porous structure, multi-drugs for cancer chemo/photothermal therapy is designed, prepared and characterized. Further, we establish a method to study the interaction between nanomotors and cells, along with their tumor permeability mechanism, including 2D cellular models, 3D multicellular tumor spheroids and in vivo models. In vivo tumor elimination results verify that the movement behaviour of the nanomotors can greatly facilitate them to eliminate tumor through multiple therapeutic methods. This work tries to establish systematic research and evaluation models, providing strategies to understand the relationship between motion behaviour and tumor permeation efficiency of nanomotors in depth.
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