期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 31, 页码 12756-12761出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202004181
关键词
copolymerization; photothermal; photodynamic effect; polymeric nanoparticles; pyrrole; tellurium
资金
- NSFC [21774130, 51925306]
- National Key R&D Program of China [2018FYA 0305800]
- Key Research Program of Frontier Sciences, CAS [QYZDB-SSW-JSC046]
- Key Research Program of the Chinese Academy of Sciences [XDPB08-2]
- Strategic Priority Research Program of Chinese Academy of Sciences [XDB28000000]
- International Partnership Program of Chinese Academy of Sciences [211211KYSB20170014]
- University of Chinese Academy of Sciences
Cancer possesses normoxic and hypoxia microenvironments with different levels of oxygen, needing different efficacies of photothermal and photodynamic therapies. It is important to precisely tune the photothermal and photodynamic effects of phototherapy nano-agents for efficient cancer treatment. Now, a series of copolymeric nanoparticles (PPy-Te NPs) were synthesized in situ by controlled oxidative copolymerization with different ratios of pyrrole to tellurophene by FeCl3. The photothermal and photodynamic effects of semiconducting nano-agents under the first near-infrared (NIR) irradiation were precisely and systematically tuned upon simply varying the molar ratio of the pyrrole to tellurophene. The PPy-Te NPs were used for cancer treatment in mice, exhibiting excellent biocompatibility and therapeutic effect. This work presents a simple method to tune photothermal and photodynamic therapies effect in semiconducting nano-agents for cancer treatment.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据