期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 31, 页码 12894-12899出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201916699
关键词
diffusion-based separations; diffusivity; electrokinetics; fractionation; microfluidics
资金
- European Research Council under the European Union's Horizon 2020 Research and Innovation Programme [678734]
- BRIDGE Proof-of-Concept program - Innosuisse (Swiss Innovation Agency)
- Swiss National Science Foundation (SNSF) [40B1-0191549]
- European Research Council (ERC) [678734] Funding Source: European Research Council (ERC)
We present a new concept for on-chip separation that leverages bidirectional flow, to tune the dispersion regime of molecules and particles. The system can be configured so that low diffusivity species experience a ballistic transport regime and are advected through the chamber, whereas high diffusivity species experience a diffusion dominated regime with zero average velocity and are retained in the chamber. We detail the means of achieving bidirectional electroosmotic flow using an array of alternating current (AC) field-effect electrodes, experimentally demonstrate the separation of particles and antibodies from dyes, and present a theoretical analysis of the system, providing engineering guidelines for its design and operation.
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