期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 31, 页码 12848-12852出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202002362
关键词
C-H activation; carboxylic acids; ligand-enabled catalysis; palladium; delta-lactones
资金
- Max Planck Society (Otto Hahn Award)
- FCI (Liebig Fellowship)
- DFG [SFB 858]
- Studienstiftung des deutschen Volkes
- WWU Munster
We report the ligand-enabled C-H activation/olefination of free carboxylic acids in the gamma-position. Through an intramolecular Michael addition, delta-lactones are obtained as products. Two distinct ligand classes are identified that enable the challenging palladium-catalyzed activation of free carboxylic acids in the gamma-position. The developed protocol features a wide range of acid substrates and olefin reaction partners and is shown to be applicable on a preparatively useful scale. Insights into the underlying reaction mechanism obtained through kinetic studies are reported.
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