期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 52, 页码 23374-23385出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202003545
关键词
functional materials; mRNA delivery; nanotechnology; regulated translation; structure-function relationship
资金
- Australian Research Council
- Queensland Government
- Queensland node of the Australian National Fabrication Facility, Australian Microscopy and Microanalysis Research Facility at the Centre for Microscopy and Microanalysis
- University of Queensland
- Science and Technology Commission of Shanghai Municipality, China [19JC1412100]
Introducing mRNA into cells has attracted intense interest for diverse applications; however, success requires delivery solutions. Engineered nanomaterials have been applied as mRNA nanocarriers; their functions are designed mainly as delivery vehicles, but rarely in regulation of the protein translation. Recently, progress in nanobiotechnology has shifted the design principle of mRNA nanocarriers from simple delivery tools to translation modulators. Here, we review the emerging concepts of nanomaterials regulating mRNA translation and recent progress in mRNA delivery. Designer nanomaterials providing integrated functions for specific mRNA applications are also reviewed to provide insights for the design of next-generation nanomaterials to revolutionize mRNA technology.
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