期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 29, 页码 11779-11783出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202000338
关键词
host-guest systems; molecular switches; photosensitizers; pillararenes; supramolecular chemistry
资金
- National Natural Science Foundation of China [21434005]
- fundamental research funds for the central universities
In order to promote the development of photodynamic therapy (PDT), undesired side effects like low tumor specificity and the always-on phenomenon should be avoided. An effective solution is to construct an adaptive photosensitizer that can be activated to generate reactive oxygen species (ROS) in the tumor microenvironment. Herein, we design and synthesize a supramolecular switch based on a host-guest complex containing a water-soluble pillar[5]arene (WP5) and an AIEgen photosensitizer (G). The formation of the host-guest complex WP5 superset of G quenches the fluorescence and inhibits ROS generation of G. Benefitting from the pH-responsiveness of WP5, the binding site between G and WP5 changes in an acidic environment through a shuttle movement. Consequently, fluorescence and ROS generation of the host-guest complex can be switched on at pH 5.0. This work offers a new paradigm for the construction of adaptive photosensitizers by using a supramolecular method.
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