期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 26, 页码 10489-10492出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202003253
关键词
molecular receptors; molecular recognition; polyaromatic cavity; stabilization; unsaturated fatty acids
资金
- JSPS KAKENHI [JP17H05359/JP18H01990/JP19H04566/JP19K23623]
- Support for Tokyo Tech Advanced Researchers (STAR)
Selective recognition of natural fatty acids is intrinsically difficult owing to the long, flexible, and poorly interactive hydrocarbon chains. Inspired by biological recognition systems, we herein demonstrate the exclusive binding of a monounsaturated fatty acid by an artificial polyaromatic receptor from a mixture of the unsaturated and corresponding saturated substrates (i.e., oleic and stearic acids) in water. The selectivity stems from multiple CH-pi/pi-pi interactions between the host framework and the guest in its roughly coiled conformation. Moreover, competitive binding experiments elucidate higher binding affinities of the receptor for oligo- and polyunsaturated fatty acids (e.g., alpha-linolenic acid and EPA). Within the receptor, the biosubstrates are remarkably stabilized against air, light, and heat owing to the polyaromatic shielding effect.
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