期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 59, 期 33, 页码 13836-13843出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202003672
关键词
dexamethasone; exosome; AIEgen hybrid nanovesicles; photodynamic therapy; tumor penetration; tumor vascular normalization
资金
- National Natural Science Foundation of China [81901771]
- Science, Technology & Innovation Commission of Shenzhen Municipality [JCYJ20190807144209381]
The development of novel photosensitizing agents with aggregation-induced emission (AIE) properties has fueled significant advances in the field of photodynamic therapy (PDT). An electroporation method was used to prepare tumor-exocytosed exosome/AIE luminogen (AIEgen) hybrid nanovesicles (DES) that could facilitate efficient tumor penetration. Dexamethasone was then used to normalize vascular function within the tumor microenvironment (TME) to reduce local hypoxia, thereby significantly enhancing the PDT efficacy of DES nanovesicles, and allowing them to effectively inhibit tumor growth. The hybridization of AIEgen and biological tumor-exocytosed exosomes was achieved for the first time, and combined with PDT approaches by normalizing the intratumoral vasculature as a means of reducing local tissue hypoxia. This work highlights a new approach to the design of AIEgen-based PDT systems and underscores the potential clinical value of AIEgens.
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