期刊
CARDIOVASCULAR AND INTERVENTIONAL RADIOLOGY
卷 39, 期 8, 页码 1177-1186出版社
SPRINGER
DOI: 10.1007/s00270-016-1364-8
关键词
Hepatic; Embolization; Image-able
资金
- CRADA
- Philips
- Biocompatibles/BTG
- Intramural Research Program of the NIH
- Center of Interventional Oncology [ZID BC011242-08]
To describe first clinical experience with a directly image-able, inherently radio-opaque microspherical embolic agent for transarterial embolization of liver tumors. LC Bead LUMI (TM) is a new product based upon sulfonate-modified polyvinyl alcohol hydrogel microbeads with covalently bound iodine (similar to 260 mg I/ml). 70-150 mu LC Bead LUMI (TM) iodinated microbeads were injected selectively via a 2.8 Fr microcatheter to near complete flow stasis into hepatic arteries in three patients with hepatocellular carcinoma, carcinoid, or neuroendocrine tumor. A custom imaging platform tuned for LC LUMI (TM) microbead conspicuity using a cone beam CT (CBCT)/angiographic C-arm system (Allura Clarity FD20, Philips) was used along with CBCT embolization treatment planning software (EmboGuide, Philips). LC Bead LUMI (TM) image-able microbeads were easily delivered and monitored during the procedure using fluoroscopy, single-shot radiography (SSD), digital subtraction angiography (DSA), dual-phase enhanced and unenhanced CBCT, and unenhanced conventional CT obtained 48 h after the procedure. Intra-procedural imaging demonstrated tumor at risk for potential under-treatment, defined as paucity of image-able microbeads within a portion of the tumor which was confirmed at 48 h CT imaging. Fusion of pre- and post-embolization CBCT identified vessels without beads that corresponded to enhancing tumor tissue in the same location on follow-up imaging (48 h post). LC Bead LUMI (TM) image-able microbeads provide real-time feedback and geographic localization of treatment in real time during treatment. The distribution and density of image-able beads within a tumor need further evaluation as an additional endpoint for embolization.
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