期刊
ANALYTICA CHIMICA ACTA
卷 1113, 期 -, 页码 66-84出版社
ELSEVIER
DOI: 10.1016/j.aca.2020.03.011
关键词
Droplet; Microfluidics; Analytical detection method; Optical detection; Electrical detection; Mass spectrometry; Nuclear magnetic resonance spectroscopy
资金
- Natural Science Foundation of Guangdong Province [2018A030313942]
- special fund of Guangdong Academy of Agricultural Science for scientific and technological talents introduction/cultivation
- special fund for science and technology innovation strategy (Construction of HighLevel Academy of Agricultural Sciences)
- William R. Wiley Environmental Molecular Sciences Laboratory [grid.436923.9]
- U.S. Department of Energy Office of science user facility - Office of Biological and Environmental Research
- U.S. Department of Energy Office of science user facility [DE-AC05-76RL01830]
Droplet-based microfluidics has emerged as a powerful platform for high-throughput and low-volume analysis and screening. At present, droplet-based microfluidics is transitioning from the proof-of-concept stage to real-world applications. During this process, analytical detection techniques play indispensable roles for successfully implementing droplet-based chemical or biological assays. In this review, we provide an overview of recent developments in analytical techniques for droplet analysis and elucidate the advantages and limitations of each technique. We cover the majority of technology categories, including optical detection, electrical detection, mass spectrometry, and nuclear magnetic resonance spectroscopy. Additionally, we highlight new research areas that have been enabled by these technical advances. Finally, we provide perspectives on both future technological directions and potential enabling applications. (C) 2020 Elsevier B.V. All rights reserved.
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