A fast and facile electrochemical method for the simultaneous detection of epinephrine, uric acid and folic acid based on ZrO2/ZnO nanocomposites as sensing material

A novel electrochemical sensor based on ZrO2 and ZnO hybrid nanocomposites was developed for simultaneous determination of epinephrine (EA), uric acid (UA) and folic acid (FA) with the highly selective and ultrasensitive. The nanocomposites have been synthesized by chemical precipitation and thermal calcine method with economical, eco-friendly and practical nature. Their structure and electrochemical properties were investigated by X-ray diffraction (XRD), X-ray photo electron spectroscopy (XPS), scanning electron microscopy (SEM) and electrochemical techniques. The results reveal that the ZrO2/ZnO nanocomposites can possesses highly exposed catalytic sites, favorable conductivity, and the sensor excellent signal response for EP, UA and FA under the optimal condition. The electrochemical sensing platform has a low detection limit of 0.039 mu M, 0.29 mu M and 0.037 mu M and a wide detection range of 0.8-420 mu M, 10-2400 mu M and 2-480 mu M, respectively. It was also tested with a human blood serum sample at physiological pH with recovery 97.3-103.8% and relation standard deviation less than 5%. It indicates that the electrochemical sensors has a hopeful capacity of extensive applications in bioanalysis and diseases diagnosis. (C) 2020 Elsevier B.V. All rights reserved.