期刊
AMERICAN JOURNAL OF TRANSPLANTATION
卷 20, 期 7, 页码 1916-1921出版社
ELSEVIER SCIENCE INC
DOI: 10.1111/ajt.15928
关键词
clinical characteristics; COVID-19; immunosuppressant; solid organ transplant recipient
资金
- National Natural Science Foundation of China [81970548, 81570079, 81700657]
- Post-Doctoral Innovative Talent Support Program
Over 1 000 000 cases of coronavirus disease 2019 (COVID-19) have been confirmed since the worldwide outbreak began. Not enough data on infected solid organ transplant (SOT) recipients are available, especially data about the management of immunosuppressants. We report two cases of COVID-19 in two transplant recipients, with different treatments and prognoses. The first patient received liver transplantation due to hepatitis B virus-related hepatocellular carcinoma and was confirmed to have COVID-19 9 days later. Following a treatment regimen consisting of discontinued immunosuppressant use and low-dose methylprednisolone-based therapy, the patient developed acute rejection but eventually recovered. The other patient had undergone a renal transplant from a living-related donor 17 years ago, and was admitted to the hospital because of persistent fever. This patient was also diagnosed with COVID-19. His treatment regimen consisted of reduced immunosuppressant use. No signs of rejection were observed during the regimen. In the end, the patient successfully recovered from COVID-19. These effectively treated cases can provide a basis for immunosuppressant management of COVID-19-positive SOT recipients.
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