期刊
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
卷 223, 期 2, 页码 211-218出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.ajog.2020.03.034
关键词
acesulfame K; aspartame; non-nutritive sweeteners; pregnancy; saccharin; stevia; sucralose
In an effort to reduce sugar consumption to prevent diabetes mellitus and cardiovascular diseases, sugar-free or no added sugar products that substitute sugar with non-nutritive sweeteners (NNSs) (eg, Splenda, Sweet'N Low, and Stevia) have become increasingly popular. The use of these products during pregnancy has also increased, with approximately 30% of pregnant women reporting intentional NNS consumption. In clinical studies with nonpregnant participants and animal models, NNSs were shown to alter gut hormonal secretion, glucose absorption, appetite, kidney function, in vitro insulin secretion, adipogenesis, and microbiome dysbiosis of gut bacteria. In pregnant animal models, NNS consumption has been associated with altered sweet taste preference later in life and metabolic dysregulations in the offspring (eg, elevated body mass index, increased risk of obesity, microbiome dysbiosis, and abnormal liver function tests). Despite the accumulating evidence, no specific guidelines for NNS consumption are available for pregnant women. Furthermore, there are limited clinical studies on the effects of NNS consumption during pregnancy and postpartum and long-term outcomes in the offspring.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据