期刊
ALLERGY
卷 76, 期 1, 页码 150-167出版社
WILEY
DOI: 10.1111/all.14355
关键词
beta-lactam; drug allergy; human leukocyte antigen; hypersensitivity; penicillin; T cell
资金
- National Health and Medical Research Council [1122099]
- National Health and Medical Research Council of Australia [1122099] Funding Source: NHMRC
Penicillin, as a first-line treatment for infections, can induce immune-mediated adverse reactions including IgE-mediated and non-IgE-mediated reactions, manifesting as skin eruptions and liver injury. Studies have shown that the infiltration of T cells at the site of inflammation is dependent on the nature of the reaction.
Penicillin refers to a group of beta-lactam antibiotics that are the first-line treatment for a range of infections. However, they also possess the ability to form novel antigens, or neoantigens, through haptenation of proteins and can stimulate a range of immune-mediated adverse reactions-collectively known as drug hypersensitivity reactions (DHRs). IgE-mediated reactions towards these neoantigens are well studied; however, IgE-independent reactions are less well understood. These reactions usually manifest in a delayed manner as different forms of cutaneous eruptions or liver injury consistent with priming of an immune response.Ex vivostudies have confirmed the infiltration of T cells into the site of inflammation, and the subsets of T cells involved appear dependent on the nature of the reaction. Here, we review the evidence that has led to our current understanding of these immune-mediated reactions, discussing the nature of the lesional T cells, the characterization of drug-responsive T cells isolated from patient blood, and the potential mechanisms by which penicillins enter the antigen processing and presentation pathway to stimulate these deleterious responses. Thus, we highlight the need for a more comprehensive understanding of the underlying genetic and molecular basis of penicillin-induced DHRs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据