期刊
AGE AND AGEING
卷 49, 期 6, 页码 1093-1096出版社
OXFORD UNIV PRESS
DOI: 10.1093/ageing/afaa073
关键词
faecal microbiota transplantation; Clostridioides (Clostridium) difficile infection; frailty; older people
资金
- Innovation Fund Denmark [8056-00006B]
Background: Clostridioides (Clostridium) difficile infection (CDI) is a leading cause of antibiotics-associated diarrhoea. Faecal microbiota transplantation (FMT) is effective for recurrent CDI and may be provided as a home treatment to frail, older people. Methods: We present four consecutive patients with recurrent CDI, treated at home using nasojejunal tube-delivered or encapsulated donor faeces. The primary outcome was combined clinical resolution and a negative CD toxin test 8 weeks post-treatment. Results: All four patients had severe CDI and all improved clinically following one FMT. Sustained resolution following one FMT was observed in one patient. Two patients had recurrence and received a second FMT using capsules; both achieved resolution. One patient who had recurrence declined from further FMT due to fear of relapse and was established on long-term vancomycin. No adverse events related to FMT were observed. Conclusion: Frail older people may benefit from FMT. Home treatment is a viable option and may be considered both for clinical cure and for palliation.
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