期刊
ADVANCED SYNTHESIS & CATALYSIS
卷 362, 期 13, 页码 2658-2665出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.202000197
关键词
Organocatalysis; Cycloadditions; Aromatization; beta; gamma-Unsaturated ketones; Dienolates
资金
- Opus programme from the National Science Centre, Poland [2016/23/B/ST5/01927]
In the manuscript, the application of beta,gamma-unsaturated ketones as precursors of electron-rich dienophiles in the organocatalytic, aromative inverse-electron-demand hetero-Diels-Alder cycloaddition is described. The reaction leads to the formation of biologically relevant benzofuran derivatives bearing additional tetrahydropyridine ring. The reaction is fully site-selective and occurs preferentially at the distal double bond of the dienolate intermediate. Given the absolute configuration assignment a step-wise mechanism has been proposed and the formation of aromatic benzofuran ring indicated as the driving force of the cascade.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据