期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 28, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.202002141
关键词
biosensors; neuromorphic devices; organic bioelectronics; PEDOT; PSS; short-term plasticity
类别
资金
- Life Science Department
- Biomedical, Metabolic and Neural Sciences Department of University of Modena and Reggio Emilia through FAR 2018
- Dipartimenti di eccellenza 2018-2022, MIUR, Italy
- Regione Emilia-Romagna through Percorso co-finanziato con risorse del Fondo Sociale Europeo Programma Operativo 2014/2020
- Biomedical, Metabolic and Neural Sciences Department of University of Modena and Reggio Emilia through FAR 2015
Specific detection of dopamine (DA) is achieved with organic neuromorphic devices with no specific recognition function in an electrolyte solution. The response to voltage pulses consists of amplitude-depressed current spiking mimicking the short-term plasticity (STP) of synapses. An equivalent circuit hints that the STP timescale of the device arises from the capacitance and resistance of the poly(3,4-ethylenedioxythiophene):polystyrenesulfonate (PEDOT:PSS) in series with the electrolyte resistance. Both the capacitance and resistance of PEDOT:PSS change with solution compositions. Dose curves are constructed from the STP timescale for each DA metabolite from pM to mM range of concentrations. The STP response of DA is distinctive from the other metabolites even when differences are by one functional group. Both STP and sensitivity to DA are larger across the patho-physiological range with respect to those to DA metabolites. Density functional theory calculations hint to a stronger hydrogen bond pattern of DA ammonium compared to cationic metabolites. The exponential correlation between STP and the binding energy of DA metabolites interacting with PEDOT:PSS indicates that the slow dynamics of ionic species in and out PEDOT:PSS is the origin of the neuromorphic STP. The sensing framework discriminates differences of nonspecific interactions of few kcal mol(-1), corresponding to one functional group in the molecule.
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