期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 24, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201909673
关键词
photoacoustic imaging; photothermal therapy; polymer dots; second near-infrared window; semiconducting polymers
类别
资金
- Macau government [FDCT 0011/2018/A1, FDCT 025/2015/A1]
- University of Macau [MYRG2014-00093-FHS, MYRG 2015-00036-FHS, MYRG201600110-FHS, MYRG2018-00081-FHS]
- NSFC [81771930]
- National Key RD Plan of China [2018YFB0407200]
- Shenzhen Science and Technology Innovation Commission [JCYJ20170307110157501]
Phototheranostic agents in the second near-infrared (NIR-II) window (1000-1700 nm) are emerging as a promising theranostic platform for precision medicine due to enhanced penetration depth and minimized tissue exposure. The development of metabolizable NIR-II nanoagents for imaging-guided therapy are essential for noninvasive disease diagnosis and precise ablation of tumors. Herein, metabolizable highly absorbing NIR-II conjugated polymer dots (Pdots) are reported for the first time for photoacoustic imaging guided photothermal therapy (PTT). The unique design of low-bandgap D-A pi-conjugated polymer (DPP-BTzTD) together with modified nanoreprecipitation conditions allows to fabricate NIR-II absorbing Pdots with ultrasmall (4 nm) particle size. Extensive experimental tests demonstrate that the constructed Pdots exhibit good biocompatibility, excellent photostability, bright photoacoustic signals, and high photothermal conversion efficiency (53%). In addition, upon tail-vein intravenous injection of tumor-bearing mice, Pdots also show high-efficient tumor ablation capability with rapid excretion from the body. In particular, both in vitro and in vivo assays indicate that the Pdots possess remarkable PTT performance under irradiation with a 1064 nm laser with 0.5 W cm(-2), which is much lower than its maximum permissible exposure limit of 1 W cm(-2). This pilot study thus paves a novel avenue for the development of organic semiconducting nanoagents for future clinical translation.
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