期刊
ADVANCED FUNCTIONAL MATERIALS
卷 30, 期 44, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201910250
关键词
3D culture; biofabrication; disease modeling; hydrogels; Parkinson's disease
类别
资金
- COINOR grant STAR Linea1-2018
- ReumaNederland [LLP-12, LLP-22]
- European Research Council [647426, 3DJOINT]
- Horizon 2020 research and innovation program [814444]
To date, pharmaceutical progresses in central nervous system (CNS) diseases are clearly hampered by the lack of suitable disease models. Indeed, animal models do not faithfully represent human neurodegenerative processes and human in vitro 2D cell culture systems cannot recapitulate the in vivo complexity of neural systems. The search for valuable models of neurodegenerative diseases has recently been revived by the addition of 3D culture that allows to re-create the in vivo microenvironment including the interactions among different neural cell types and the surrounding extracellular matrix (ECM) components. In this review, the new challenges in the field of CNS diseases in vitro 3D modeling are discussed, focusing on the implementation of bioprinting approaches enabling positional control on the generation of the 3D microenvironments. The focus is specifically on the choice of the optimal materials to simulate the ECM brain compartment and the biofabrication technologies needed to shape the cellular components within a microenvironment that significantly represents brain biochemical and biophysical parameters.
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