期刊
ADVANCED DRUG DELIVERY REVIEWS
卷 165-166, 期 -, 页码 142-154出版社
ELSEVIER
DOI: 10.1016/j.addr.2020.05.004
关键词
Medical microdevices; Gastrointestinal tract; Gut microbiota; Oral drug delivery; GI diagnostics
资金
- H.C. Orsted COFUND
- European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie Grant [713683]
- Excellence PhD Scholarship from DTU Health Tech
- Novo Nordisk Foundation [NNF17OC0026910]
- Danish National Research Foundation [DNRF122]
- Villum Fonden [9301]
Orally ingestible medical devices provide significant advancement for diagnosis and treatment of gastrointestinal (GI) tract-related conditions. From microto macroscale devices, with designs ranging from very simple to complex, these medical devices can be used for site-directed drug delivery in the GI tract, real-time imaging and sensing of gut biomarkers. Equipped with uni-direction release, or self-propulsion, or origami design, these microdevices are breaking the barriers associated with drug delivery, including biologics, across the GI tract. Further, on-board microelectronics allow imaging and sensing of gut tissue and biomarkers, providing a more comprehensive understanding of underlying pathophysiological conditions. We provide an overview of recent advances in orally ingestible medical devices towards drug delivery, imaging and sensing. Challenges associated with gut microenvironment, together with various activation/actuation modalities of medical devices for micro manipulation of the gut are discussed. We have critically examined the relationship between materials-device design-pharmacological responses with respect to existing regulatory guidelines and provided a clear roadmap for the future. (C) 2020 Elsevier B.V. All rights reserved.
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