期刊
ACTA NEUROLOGICA BELGICA
卷 121, 期 6, 页码 1505-1512出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s13760-020-01369-4
关键词
Alzheimer's disease (AD); Interleukin-6 (IL-6); Interleukin-8 (IL-8); Interleukin-10 (IL-10); Gene polymorphisms; Meta-analysis; Asians
This meta-analysis suggests a potential relationship between gene polymorphisms in IL-6, IL-8, and IL-10 and predisposition to Alzheimer's disease, with specific alleles like IL-6 - 174 G/C, IL-6 - 572 G/C, and IL-10 - 1082 A/G potentially influencing AD susceptibility. The study also found significant differences in genotypic frequencies among different populations, highlighting a potential genetic component in AD predisposition.
Gene polymorphisms in interleukin-6 (IL-6), interleukin-8 (IL-8), and interleukin-10 (IL-10) may affect the predisposition of Alzheimer's disease (AD), but the results of the so far published studies remain controversial. The authors conducted this meta-analysis to assess relationships between IL-6/IL-8/IL-10 polymorphisms and predisposition of AD by pooling the findings of so far published studies. A comprehensive search of Pubmed, Embase, Web of Science, and CNKI was endorsed by the authors to identify the already published studies. Forty-five studies were found to be eligible for meta-analyses. The pooled meta-analyses results showed that genotypic frequencies of IL-6 - 174 G/C, IL-6 - 572 G/C and IL-10 - 1082 A/G polymorphisms among patients with AD and controls differed significantly. Moreover, genotypic frequencies of IL-6 - 174 G/C, IL-6 - 572 G/C, and IL-8 - 251 A/T polymorphisms among patients with AD and controls in Asians also differed significantly. But no such genotypic frequencies' differences were observed for IL-10 - 819 C/T and 592 C/A polymorphisms. This meta-analysis suggests that IL-6 - 174 G/C, IL-6 - 572 G/C, and IL-10 - 1082 A/G polymorphisms may affect the predisposition of AD in overall population. Moreover, IL-6 - 174 G/C, IL-6 - 572 G/C, and IL-8 - 251 A/T polymorphisms may affect the predisposition of AD in Asians.
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