期刊
ACS NANO
卷 14, 期 6, 页码 7181-7190出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c02138
关键词
amyloid-like structure; self-assembly; dipeptide; stimuli-responsive; supramolecular chemistry
类别
资金
- European Research Council under the European Union Horizon 2020 research and innovation program [694426]
- National Natural Science Foundation of China [21522307, 21773248, 21802144, 21802143]
- National Natural Science Fund BRICS STI Framework Programme [51861145304]
- Innovation Research Community Science Fund [21821005]
- Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) [QYZDB-SSW-JSC034]
Conformational transition of proteins and peptides into highly stable, beta-sheet-rich structures is observed in many amyloid-associated neurodegenerative disorders, yet the precise mechanism of amyloid formation at the molecular level remains poorly understood due to the complex molecular structures. Short peptides provide simplified models for studying the molecular basis of the assembly mechanism that governs beta-sheet fibrillation processes underlying the formation and inhibition of amyloid-like structures. Herein, we report a supramolecular coassembly strategy for the inhibition and transformation of stable beta-sheet-rich amyloid-derived dipeptide self-assemblies into adaptable secondary structural fibrillar assemblies by mixing with bipyridine derivatives. The interplay between the type and mixing ratio of bipyridine derivatives allowed the variable coassembly process with stimuli-responsive functional properties, studied by various experimental characterizations and computational methods. Furthermore, the resulting coassemblies showed functional redox- and photoresponsive properties, making them promising candidates for controllable drug release and fluorescent imprint. This work presents a coassembly strategy not only to explore the mechanism of amyloid-like structure formation and inhibition at the molecular level but also to manipulate amyloid-like structures into responsive supramolecular coassemblies for material science and biotechnology applications.
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