期刊
ACS NANO
卷 14, 期 4, 页码 4595-4600出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.0c00164
关键词
reconfigurable; self-assembly; DNA-coated colloids; crystal transformation; DNA hybridization kinetics
类别
资金
- Department of Energy (DOE) [DE-SC0007991]
- National Research Foundation of Korea (NRF) [2017M3A7B8065528, 2017R1A5A1070259]
- Materials Research Science and Engineering Centers program of the NSF [DMR-1420073]
- National Research Foundation of Korea [2017M3A7B8065528] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
- U.S. Department of Energy (DOE) [DE-SC0007991] Funding Source: U.S. Department of Energy (DOE)
DNA is a unique molecule for storing information, which is used to provide particular biological instructions. Its function is primarily determined by the sequence of its four nucleobases, which have highly specific base-pairing interactions. This unique feature can be applied to direct the self-assembly of colloids by grafting DNA onto them. Due to the sequence-specific interactions, colloids can be programmed with multiple instructions. Here, we show that particles having multiple DNA strands with different melting profiles can undergo multiple phase transitions and reassemble into different crystalline structures in response to temperature. We include free DNA strands in the medium to selectively switch on and off DNA hybridization depending on temperature. We also demonstrate that DNA hybridization kinetics can be used as a means to achieve targeted assembling structure of colloids. These transitions impart a reconfigurability to colloids in which systems can be transformed an arbitrary number of times using thermal and kinetic control.
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