期刊
ACS NANO
卷 14, 期 4, 页码 4383-4394出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsnano.9b09974
关键词
galvanic replacement; nanozyme; hypoxia; phototherapy; ruthenium
类别
资金
- National Research Foundation of Korea (NRF) - Korean government [NRF-2019R1C1C1002305]
- Basic Science Research Program [2016R1E1A1A01941202, 2016R1A4A1010796]
- Research Center Program of IBS through the NRF [IBS-R008-D1]
- Nano.Material Technology Development Program through the NRF - Ministry of Science, ICT and Future Planning [2009-0082580]
- National Research Foundation of Korea [IBS-R008-D1-2020-A00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Nanozymatic reactions that produce or consume oxygen (O-2) or reactive oxygen species (ROS) consist of oxidase, peroxidase, superoxide dismutase (SOD), and catalase-type activity. Although extensive studies were conducted to overcome hypoxia through nanozymatic reactions, the construction of an ideal system is challenging, given that the reactants and products are arranged in a recurring structure for continuous consumption in a full cycle. In this study, speckled Ru-Te hollow nanorods were prepared through solvothermal galvanic replacement against Te nanorod templates with high yield and robustness. From their multicompositional characteristics, nonrecurring peroxidase-SOD-catalase-type nanozymatic properties were identified with photothermal and photodynamic feasibility over a wide range of laser irradiation wavelengths. Owing to the excellent colloidal stability and biocompatibility, the proposed Ru-Te-based nanozymatic platform was highly effective in hypoxic pancreatic cancer phototherapy in vitro and in vivo by near-infrared laser irradiation mediated photothermal and photodynamic combination treatment.
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