期刊
ACS CHEMICAL BIOLOGY
卷 15, 期 3, 页码 602-617出版社
AMER CHEMICAL SOC
DOI: 10.1021/acschembio.9b01015
关键词
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资金
- National Institutes of Health [U01CA242098-01]
- Burroughs Welcome Fund, a Career Award at the Scientific Interface
- Sloan Foundation
- Harvard University
O-Linked N-acetyl glucosamine (O-GlcNAc) is a protein modification found on thousands of nudear, cytosolic, and mitochondrial proteins. Many O-GlNAc sites occur in proximity to protein sites that are likewise modified by phosphorylation. While several studies have uncovered crosstalk between these two signaling modifications on individual proteins and pathways, an understanding of the role of O-GlcNAc in regulating kinases, the enzymes that install the phosphate modification, is still emerging. Here we review recent methods to profile the O-GlcNAc modification on a global scale that have revealed more than 100 kinases are modified by O-GlcNAc and highlight existing studies about regulation of these kinases by O-GlcNAc. Continuing efforts to profile the O-GlcNAc proteome and understand the role of O-GlcNAc on kinases will reveal new mechanisms of regulation and potential avenues for manipulation of the signaling mechanisms at the intersection of O-GlcNAc and phosphorylation.
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