期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 23, 页码 25676-25682出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c07356
关键词
MOFs; pulmonary delivery; microencapsulation; mannitol; MIL-100 nanoparticles
资金
- Xunta de Galicia [ED431C 2017/09-FEDER]
- regional Madrid founding (Talento 2017 Modality 2) [2017-T2/IND-5149]
- Multifunctional Metallodrugs in Diagnosis and Therapy Network (MICIU) [RED2018-102471-T]
- Spanish Ramon y Cajal Programme [2014-16823]
Although nanoscaled metal-organic frameworks (nanoMOFs) are promising drug carriers, their appropriate formulation remains almost unexplored and basically restricted to intravenous routes. Lungs, beneficiating from a large absorption surface and low enzymatic presence, are a very attractive target for both local and systemic delivery. However, pulmonary nanoMOF formulation is a pending and defying task. Thus, we propose a pioneer nanoMOF-based microsphere system as a potential platform for pulmonary administration. A biocompatible nanoMOF was successfully encapsulated in mannitol by a simple and continuous spray-drying technique. Upon intratracheal administration to rats, the resulting formulation, exhibiting optimal properties (i.e., homogeneity, size, density, and spray-drying process yield), was able to release the intact nanoMOF carrier uniformly along the lungs, reaching the bronchioles and alveoli.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据