期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 23, 页码 25565-25571出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c04317
关键词
bifunctional polymer; cascade reaction; colorimetric assay; enzymatic catalysis; glucose detection
资金
- National Natural Science Foundation of China [21505147, 21675140]
- Taishan Scholar Program of Shandong Province [ts201511027]
- Natural Science Foundation of Shandong [2018GGX102030]
The encapsulation of multiple enzyme/nanoenzyme systems within mental-organic frameworks (MOFs) shows great promise for a myriad of practical applications. Herein, two sequential biocatalysts, oxidase and hemin, were coupled together with close proximity using a bifunctional polymer, poly(1-vinylimidazole) (PVI), and encapsulated into MOFs. As a demonstration of the power of such a protocol, glucose oxidase&PVI-hemin encapsulated in ZIF-8 showed significant enhancement of bioactivity for a cascade reaction compared to its counterpart without PVI. For the colorimetric assay of glucose, it showed a low limit of detection of 0.4 mu M (S/N = 3), high selectivity, and excellent stability. Because there are numerous biocatalysts that can readily be coupled and encapsulated into MOFs, a myriad of interesting properties can be simply realized by encapsulating different sequential biocatalysts.
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