期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 22, 页码 24564-24574出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c02826
关键词
glutamate; biosensor; nickelate; in vivo; strong correlated materials
资金
- AFOSR [FA9550-19-1-0351]
- DOE Office of Science [DE-AC02-06CH11357]
- National Science Foundation (United States) [DMR-0703406, ECCS-1944480, CNS-1726865]
- U.S. Department of Energy, Office of Science [DE-AC02-06CH11357]
Glutamate, one of the main neurotransmitters in the brain, plays a critical role in communication between neurons, neuronal development, and various neurological disorders. Extracellular measurement of neurotransmitters such as glutamate in the brain is important for understanding these processes and developing a new generation of brain-machine interfaces. Here, we demonstrate the use of a perovskite nickelate-Nafion heterostructure as a promising glutamate sensor with a low detection limit of 16 nM and a response time of 1.2 s via amperometric sensing. We have designed and successfully tested novel perovskite nickelate-Nafion electrodes for recording of glutamate release ex vivo in electrically stimulated brain slices and in vivo from the primary visual cortex (V1) of awake mice exposed to visual stimuli. These results demonstrate the potential of perovskite nickelates as sensing media for brain-machine interfaces.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据