期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 14, 页码 16031-16039出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b23177
关键词
melanoma; CuS; homologous Targeting; photothermal therapy; photoacoustic imaging
资金
- Natural Science Foundation of China [81871578, 81772285]
- Shanghai Science and Technology Commission Medical Guidance Project [17411968700, 18441900300]
- Shanghai Health System Excellent Personnel Training Program [2017YQ051]
- Postdoctoral Innovation Talent Support Program of China [201700173]
- Shanghai Municipal Science and Technology Commission [13JC1401403]
Modulating the surface properties of nanoparticles (NPs) is an important approach to accomplish immune escape, prolonged the blood retention time, and enhance the ability of targeted drug delivery. The camouflage of cancer cell membrane onto nanoparticles has been proved to be an ideal approach to enhance active targeting ability of NPs. Herein, we isolated the membrane of melanoma cells to coat doxorubicin (DOX) and indocyanine green (ICG)-loaded hollow copper sulfide NPs (ID-HCuSNP@B16F10) for targeted photothermal therapy, photoacoustic imaging, and chemotherapy. A remarkable in vitro anticancer effect after irradiation and homologous targeting can be observed in B16F10 cells after the treatment of ID-HCuSNP@ B16F10. Moreover, ID-HCuSNP@B16F10 exhibits excellent photothermal effect in melanoma animal models and achieves a high tumor ablation rate. This biomimetic system can realize high drug loading efficiency, enhanced targeting ability, and ideal antitumor efficiency.
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