期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 20, 页码 22499-22506出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c03001
关键词
radiation dosimetry; colorimetric detection; silver nanoprisms; gold nanorods; dual-color nanosensor
资金
- National Institute of Health [CA174653, R01CA158073, CA197606]
- Leukemia Lymphoma Society Scholar Award
- National Natural Science Foundation of China [21907113, 51903256]
- Guangdong Province Science and Technology Innovation Special Fund (International Scientific Cooperation) [2018A050506035]
Radiation dosimeters are critical for accurately assessing the levels of radiation exposure of tumor sites and surrounding tissues and for optimizing therapeutic interventions as well as for monitoring environmental exposure. To fill the need for a simple, user-friendly, and inexpensive dosimeter, we designed an innovative colorimetric nanosensor-based assay for detecting ionizing radiation. We show that hydroxyl radicals generated by ionizing radiation can be used to etch gold nanorods (AuNRs) and silver nanoprisms (AgNPRs), yielding reproducible color changes for radiation dose detection in the range of 50-2000 rad, broad enough to cover doses used in hyperfractionated, conventional, and hypofractionated radiotherapy. This range of doses detected by this assay correlates with radiation-induced DNA damage response in mammalian cells. Furthermore, this AuNR- and AgNPR-based sensing platform has been established in a paper format that can be readily adopted for a wide range of applications and translation.
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