期刊
ACS APPLIED MATERIALS & INTERFACES
卷 12, 期 14, 页码 16150-16158出版社
AMER CHEMICAL SOC
DOI: 10.1021/acsami.0c02647
关键词
light irradiation; antibiotics; photodynamic antibacterium; reactive oxygen species; photosensitizer
资金
- National Natural Science Foundation of China [21475031, 21605034]
- Natural Science Foundation of Hebei Province [B2018201049, B2017201184]
The irrational or excessive use of antibiotics causes the emergence of bacterial resistance, making antibiotics less effective or ineffective. As the number of resistant antibiotics increases, it is crucial to develop new strategies and innovative approaches to potentiate the efficacy of existing antibiotics. In this paper, we report that some existing antibiotics can produce reactive oxygen species (ROS) directly under light irradiation. Thus, a novel antibacterial photodynamic therapy (PDT) strategy is proposed by using existing antibiotics for which the activities are potentiated via light-activation. This antibiotic-based PDT strategy can achieve efficient bacteria killing with a low dosage of antibiotics, indicating that bacterial killing can be enhanced by the light-irradiated antibiotics. Moreover, the specific types of ROS produced by different antibiotics under light irradiation were studied for better elucidation of the antibacterial mechanism. The findings can extend the application of existing antibiotics and provide a promising strategy for treatment of bacterial infections and even cancers.
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